Novel Pathway Involved in Neurodevelopmental Toxicity of PCBs

Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) are widespread environmental contaminants previously associated with neurological disorders in children. In a new study funded in part by the University of California (UC), Davis Superfund Research Program, UC Davis investigators working in collaboration with colleagues at Washington State University demonstrated a novel mechanism of PCB developmental neurotoxicity. Despite extensive research documenting that PCBs interfere with normal neurodevelopment, only recently have adverse outcome pathways of PCB developmental neurotoxicity been described. In this study, researchers extend on observations to explain one way NDL PCBs may be potential environmental risk factors for impaired brain development.